Platelet STING agonism and venous thrombosis: translational implications for improved disease outcomes.

Abstract

The study by Yang et al.3 is intriguing in defining an important role played by STING activation in platelets on corollary development of platelet aggregation with neutrophils, NETosis and VTE in the setting of CLP-induced sepsis. This thrombotic paradigm may be relevant to a broad range of infectious diseases, autoimmune conditions and cancers in association with disease comorbidity or with adverse events to therapy. Judicious use of targeted antagonists to regulate or counteract platelet STING-dependent VTE may improve outcomes for these patients.