Platelet-rich plasma injection and becaplermin gel as effective dressing adjuvants for treating chronic nonhealing ulcers in patients with junctional epidermolysis bullosa

Abstract

Chronic wounds in junctional epidermolysis bullosa (JEB) are associated with significant morbidity and pose a considerable economic burden, especially in resource-limited settings. Because of lack of definitive treatment, advanced silicone foam–based dressings are recommended for wound care, but their scarcity in developing countries leads, instead, to overzealous use of paraffin gauze.1 Platelet-rich plasma is known to benefit chronic ulcers by virtue of various growth and angiogenic factors, and becaplermin is also beneficial in nonhealing ulcers of various etiologies.