Abstract
Platelet-rich plasma (PRP) is a rich source of plateletderived growth factors such as PDGF, TGF and VEGF, making it a potential material in tissue regeneration, especially in regenerative medicine. Due to the limitation of ethical issues for direct research on humans, this study aimed to collect PRP from peripheral blood of the mouse and evaluate its features as platelet concentration, the structure of activated PRP gel, in vitro cytotoxicity and biological characteristics through migration with mouse bone marrow cells. The results showed that the platelet concentration of PRP was five times higher than that in whole blood and PRP has a dense fibrin network after activating by CaCl2 after 10 minutes. PRP is not only safe for cells but also supports bone marrow cells to migrate and close the gap. With these results, PRP can be seen as a material with a considerable potential for wound healing, especially regenerative medicine.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
