Abstract
Background: During the coagulation and inflammation phase of wound healing, a fibrin network assembles and thrombocytes (TC) and Monocytes/Macrophages integrate in the clot secreting multiple growth factors (PDGF, VEGF, EGF, IL-1 and IGF). This tightly orchestrated cellular and hormonal balance is essential to construct the baseline granulation tissue in which subsequent proliferation and remodellation can proceed. Treatments accelerating or sustaining this initial response, could promote Full Thickness Skin Wound (FTW) healing.
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