Platelet-rich fibrin used in regenerative endodontics and dentistry: Current uses, limitations, and future recommendations for application

Abstract

Numerous strategies, including pulp implantation, revascularization, and postnatal stem cell treatments, have been developed by regenerative endodontics. Revascularization has been effectively used in clinical settings recently, giving dentists amazing outcomes. When administered alone or in conjunction with a bone transplant, platelet-rich fibrin (PRF) encourages bone development and vascularization. There are many uses for PRF in regenerative endodontics, including as a tool for mending iatrogenic pulpal floor perforations and for revascularizing developing permanent teeth with necrotic pulps. It serves as a matrix for the ingrowth of tissue. It was seen that the dentinal walls thickened with time, the roots lengthened, the periapical pathology regressed, and the apex closed. The specific mechanism of action of PRF for dental pulp rejuvenation, including both vitro and in vivo, necessitates further study.