Platelet-rich Fibrin for Chronic Wounds Management

Abstract

Background: A chronic wound can be defined as any wound that fails to heal within a reasonable period. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate. It is safe, simple, affordable and less expensive procedure in treatment of chronic wounds. Objective: This study aimed to assess safety and effectiveness of platelet-rich fibrin for treatment of chronic wounds. Patients and methods: This prospective study included 50 patients with chronic ulcer not responding to conventional therapy for at least 6 weeks, normal values blood tests especially platelet count, red blood cell count and serum albumin level. Debridement of the necrotic tissues was done using surgical and chemical debridement. The fibrin clot membrane was applied to the ulcer followed by paraffin gauze and secondary sterile dry dressing. Results: Complete wound healing occurred in 18 of 50 patients before 8th week of therapy (36%). A decrease in the mean area was observed from 7.22 ± 5.80 cm2 before treatment to 0.98 ± 1.52 cm2 after 8 weeks of therapy, which was highly significant. Conclusions: The use of PRF is effective, simple, affordable and inexpensive method allowing acceleration of healing of chronic wounds.