Platelet-rich fibrin effect on increasing free fat graft survival

Abstract

Platelet-rich fibrin is a second-generation platelet concentrate, prepared from centrifuged blood. PRF is a fibrin clot rich in platelets without addition of thrombin during preparation. PRF would necessarily have very different effects from PRP, which would have a massive, uncontrollable, and short-term effect, because of the high thrombin rates initiate fast polymerization, which makes intimate incorporation of the cytokines in the fibrin matrix difficult. PRF derives from a natural and progressive polymerization occurring during centrifugation.