Platelet rich fibrin and alloplast in treatment of intrabony defect

Abstract

Abstract Background For complete periodontal regeneration, delivery of growth factors in a local environment holds a great deal in adjunct to bone grafts. Platelet rich fibrin (PRF) is considered as second generation platelet concentrate, consisting of viable platelets, releasing various growth factors like PDGF, VEGF, TGF, IGF, EGF and bFGF. Hence, this case report aims to investigate the clinical and radiological (bone fill) effectiveness of autologous platelet rich fibrin (PRF) along with use of alloplastic bone mineral in the treatment of intra bony defects. Methods Intrabony defect was treated with autologous platelet rich fibrin (PRF) along with use of alloplastic bone mineral. Results A decrease in probing pocket depth, gain in clinical attachment level and significant bone fill was observed at end of 6 months. Discussion The result obtained with the use of Platelet Rich Fibrin may be attributed to the sustained and simultaneous release of various growth factors over a period of 7 days. Conclusion According to the results obtained in this case report, it could be concluded that the positive clinical impact of additional application of PRF with alloplastic graft material in treatment of periodontal intrabony defect.