Platelet-rich fibrin: A promising regenerative material

Abstract

Periodontal regeneration is a process involving biological events such as cell adhesion, migration, proliferation, and differentiation in an orchestrated sequence. It is well known that platelets play a key role in hemostasis and the wound healing process. Platelets were introduced as regenerative potential. Choukroun et al. (2001) first described platelet-rich fibrin (PRF). It is the second generation of platelet concentration. It consists of a natural fibrin matrix. It is autogenous fibrin made up of the patient’s blood free from anticoagulants. It is three-dimensional architecture consisting of the specific composition of leukocyte and platelet-rich fibrin biomaterials. Various technique has been used in the preparation of PRF but Choukroun’s PRF technique is the most common and easy technique developed in France. The patient’s blood was taken at around 5 ml which is collected in each of the two sterile vacutainer tubes with a 6 ml capacity without anticoagulant and centrifugation. PRF is used in various fields such as endodontics, oral and maxillofacial surgery, periodontics, and tissue engineering. It is more economical and easy preparation than other grafts. PRF should be handled properly before it shrinks and gets dehydrated. It is the most successful periodontal regenerative material.