Platelet-rich autologous plasma: what is it and for what?

Abstract

Platelet-rich autologous plasma (PRP) is often used in various branches of medicine. The scope of PRP therapy has expanded from stimulating bone regeneration, healing wounds and ulcers, and musculoskeletal injuries to improving the ability to engrave various types of grafts. Due to the natural properties of platelet-rich plasma, its introduction into the human body is one of the most promising procedures for tissue restoration. After the destruction of platelets, PRP contains α-granules, from which many factors are released after activation, such as transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VGFF) and epidermal growth factor (EGF). The current state of the problem of using APOT has a huge perspective on the development of the methodology, which is due to many aspects that make this procedure simple. PRP can improve the course of many urological diseases, such as erectile dysfunction, Peyronie’s disease, urethral stricture, vesicovaginal fistulas, interstitial cystitis, and stress urinary incontinence. There are many protocols for preparing PRP, each of which has its standardized parameters and stated results. The article presents a review of the literature on the use of platelet-rich plasma in urology, focuses on the definition of PRP, various methods of preparation and activation, as well as the concentration of growth factors.