Abstract
Collagen - induced (5-80 w g/ml) efflux of free noradrenaline (NA) and adrenaline (Ad) from platelets in plateletrich plasma was compared in normal human subjects and heterozygous familial hypercholesterolaemic (FH) patients. Stimulated release of NA and Ad to the plasma (platelet - poor; PPP) increased in a dose - dependent fashion in both normal and FH groups. Under resting conditions (0 w g/ml collagen) PPP NA concentrations were increased in hypercholesterolaemics by 38% (non - significant). The absolute amounts of NA released on stimulation with 5 w g/ml and 10 w g/ml collagen (i.e. the differences between resting and stimulated release) were reduced in hypercholesterolaemics by 45% (p<0.01) and 38% (p<0.02), respectively. Collagen EC 50 values for NA and Ad release were increased in hypercholesterolaemics by 118% (p<0.001) and 141% (p<0.05). Combining the data for the normal and FH groups revealed that the collagen EC 50 values for NA release correlated positively with plasma total cholesterol (p<0.02) and low - density lipoprotein (p<0.02). These data provide additional evidence for catecholaminergic abnormalities in hypercholesterolaemia.
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