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Abstract
AbstractObesity‐related non‐communicable diseases are global health issues. More than 50% of men and women are overweight or obese in the UK, which is associated with increased risk of cardiovascular disease (CVD) among other non‐communicable diseases. Early detection of the risk of CVD development within high‐risk groups is urgently needed to reduce the burden of this disease. Several mechanisms underlie the increased risk of CVD in overweight and obese individuals, yet non‐invasive molecular markers for risk prediction are not readily available. With the support of funding from the British Nutrition Foundation Drummond Pump Priming Award, we examined platelet mitochondrial DNA methylation in overweight and obese participants at baseline in relation to future CVD incidence. In this article, the findings from the project supported by the British Nutrition Foundation and future directions are described.
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