Abstract
The aim of this study was to investigate the predictive value of white blood cells (WBC), the neutrophil to lymphocyte ratio (NLR), platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), platelet crit (PCT) and platelet to lymphocyte ratio (PLR) in discrimination between benign and malign endometrial lesions, and early and advanced stage endometrial adenocarcinomas. Data for 105 patients undergoing total abdominal or vaginal hysterectomy for benign uterine diseases and 114 patients surgically staged for endometrium adenocarcinoma at Ondokuz Mayis University, Department of Gynecology and Obstetrics, between 2008 and 2014, were collected. Parameters were preoperative and postoperative complete blood counts in the week prior to surgery with differentials including WBC, platelet count, platelet indices (MPV, PCT, PDW), NLR and PLR. Pathologic evaluations for both benign and malign endometrium lesions, grade of endometrium adenocarcinoma, tumor stage, presence of lymphovascular space invasion (LVI) were retrospectively analyzed. Regarding definitive factors in discriminating patients with endometrium cancer from those with benign diseases, MPV was significantly increased in the malign group whereas there was a significant decrease in the PDW value compared to the benign group. The best cut-off value in differentiation of the benign and malign groups, malign cases were found to increase over the value of 7.54 for MPV, and under 37.8 for PDW. When definitive factors in discrimination of early stage endometrium cancer from advanced stage disease and LVI in the malign group were evaluated according to the ROC analysis, no significant relation was detected between blood parameters and the stage and the LVI of the disease. MPV and PDW may have predictive value in the discrimination of benign and malign endometrium diseases. Nevertheless, since there have been few reports on this topic, further large-scale prospective studies are necessary.
Highlights
Regarding definitive factors in discriminating patients with endometrium cancer from those with benign diseases, mean platelet volume (MPV) was significantly increased in the malign group whereas there was a significant decrease in the platelet distribution width (PDW) value compared to the benign group
When definitive factors in discriminating patients with endometrium cancer from those with benign diseases, MPV was significantly increased in the malign group whereas there was a significant decrease in PDW value compared to the benign group, so that MPV and PDW were assessed as significant markers in differentiating benign diseases and endometrium cancer according to the receiver operator characteristic (ROC) analysis (AUC: 0.702, 95% CI: 0.633-0.771, p
We aimed to find out the predictive value of the preoperative alterations of the complete blood count parameters in the discrimination of the benign and malign endometrium diseases and differentiation of early and advanced stage endometrial cancer
Summary
The alterations in the preoperative systemic inflammatory response (SIR) markers including, absolute white blood cells (WBC), platelet count, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), have been the focus of many investigations in terms of their prognostic and predictive values in several types of benign and malign diseases such as, cardiac-pulmonary diseases, preeclampsia, gynecologic and gastrointestinal malignancies (Ayhan et al, 2006; Kaya et al, 2013; Acmaz et al, 2014; Avci et al, 2014; Kayadibi et al, 2014; Williams et al, 2014; Kokcu et al, 2015; Kurtoglu et al, 2015).Among these studies, the relationship between the SIR markers and benign and malign diseases of the endometrium has been of little interest. The alterations in the preoperative systemic inflammatory response (SIR) markers including, absolute white blood cells (WBC), platelet count, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), have been the focus of many investigations in terms of their prognostic and predictive values in several types of benign and malign diseases such as, cardiac-pulmonary diseases, preeclampsia, gynecologic and gastrointestinal malignancies (Ayhan et al, 2006; Kaya et al, 2013; Acmaz et al, 2014; Avci et al, 2014; Kayadibi et al, 2014; Williams et al, 2014; Kokcu et al, 2015; Kurtoglu et al, 2015). Since there have been few reports on this topic, further large-scale prospective studies are necessary
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