Abstract
Previous reports of elevated platelet serotonin (5-HT) concentrations in autistic subjects suggest that platelet 5-HT uptake might be altered in autism. Parameters of 3H-imipramine (IMI) binding were measured in 11 drug-free autistic subjects and 10 normal volunteers. Similar means (±SD) for B max(autistics, 1350 ± 171 fmole / mg protein; normals, 1590 ± 206 fmole / mg protein) and K d(autistics, 0.98 ± 0.10 n M; normals, 0.94 ± 0.13 n M) were found in the two groups. The normal number ( B max) and affinity ( K d) of the IMI binding site in autistic subjects suggest that the regulation of 5-HT uptake is not different in autism.
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