Abstract
Some platelet functions have been investigated in a group of 35 subjects with chronic cerebrovascular disorders (CVP) and in a group of 30 age-matched controls. In CVP an increased average platelet adhesiveness to glass beads exists (P < 0.01), an increased platelet aggregation by ADP (0.15 μM), but not by collagen, in respect to age-matched controls. However, a wide overlapping has been observed for the data of CVP and of controls. Furthermore, these changes are not specific, as they have also been observed in a group of subjects with history of myocardial infarction. In CVP the residual aggregation at the 5th min by ADP (0.5 μM) is increased in respect to controls. The residual aggregation of control PRP is increased by addition of PPP of CVP. No differences have been observed in nucleotides and 14C-serotonine release from the platelets of CVP and of controls. In CVP the average survival time of 51Cr-platelets is decreased (7.6 ± 1.9 days instead of 9.1 ± 1.2; P < 0.01). The contemporary determination of platelet and fibrinogen survival time investigated by 75Se-seleniomethionine resulted in an average decreased in CVP in respect to the controls. Fibrinogen survival time resulted 7.4 ± 0.9 days instead of 9.3 ± 1.8 for controls (P < 0.01) and platelet survival time 8.5 ± 2.1 days instead of 10.2 ± 1.1 for controls (P < 0.01). In the CVP a good correlation can be observed between platelet and fibrinogen survival time (r = 0.783, P < 0.01).
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