Abstract
Spontaneous P-selectin surface expression on platelets and plateletleukocyte adhesion was increased in patients with symptomatic coronary heart disease (n=12) compared to normal controls (n=10) (p<0.05). ADP-induced P-selectin expression and platelet-leukocyte adhesion was also enhanced in the patient group (p<0.05). Administration of intravenous Mg 2+ significantly reduced both platelet surface expression of P-selectin and platelet-leukocyte adhesion ex vivo (p<0.02). The effect of extracellular Mg 2+ was evaluated in in vitro experiments. Both in whole blood and in isolated neutrophil suspension Mg 2+ inhibited platelet adhesion to neutrophils dose dependently with half maximal effects at 4 mM. Moreover, Mg 2+ inhibited adhesion of isolated platelet membranes to neutrophils. We conclude that platelet function is altered in symptomatic coronary heart disease and can be modulated by administration of intravenous Mg 2+.
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