Abstract
To determine the alterations of mean platelet volume (MPV), platelet distribution width (PDW), platelet level and hemoglobin level in pregnancies with threatened preterm labor (TPL). The retrospective analysis of 201 pregnant women with threatened preterm labour admitted to our clinic between 2009 and 2013 and 192 healthy pregnancies was conducted. The data regarding the maternal age, hemoglobin level, platelet count, mean platelet volume (MPV), platelet distribution width (PDW) was evaluated. The mean MPV and hemoglobin levels were significantly lower in TPL group (p=0.001 and p=0.01, respectively). PDW levels were significantly higher in TPL group (p=0.05). (p=0.01). Regarding the platelet count, there was no statistically significant difference between the TPL and control groups. ROC curve analysis for PDW revealed an area under curve (AUC) 66.8%. By using a cut-off value 16.15 for PDW, sensitivity was 76.1% and specificity was 43.5% for TPL. MPV seems to be lower in threatened preterm deliveries, whereas PDW levels were increased suggesting the possible high grade inflammation and platelet activation in the pathology. Anemia occurs more frequently in threatened preterm delivery. Increased PDW levels especially > 16.15 may alert the obstetrician for the risk of the preterm delivery. However, further studies are needed to state the usefulness of the platelet indices in the diagnosis and clinical follow-up of preterm labor.
Highlights
Preterm delivery involves births before 37 gestational weeks and accounts for approximately 10% of all deliveries.[1]
Mean platelet volume and platelet distribution width levels of the study and control groups are shown in Table-II
mean platelet volume (MPV) levels were significantly lower in threatened preterm labor (TPL) group (p=0.01); whereas platelet distribution width (PDW) levels were significantly higher in TPL group (p=0.05) (ROC curve analysis for PDW revealed an area under curve (AUC) 66.8%
Summary
Preterm delivery involves births before 37 gestational weeks and accounts for approximately 10% of all deliveries.[1]. It is well known that in preterm delivery, some inflammatory cytokines are increased both in maternal-fetal interface and systemic circulation.[5] there was no much data regarding the relation between platelet activation and preterm labor. Our objective in this study was to evaluate the alterations of platelet indices and investigate whether they can be used as a predictor marker for threatened preterm birth. To the best of our knowledge, alterations in MPV and PDW in pregnancies with threatened preterm labor (TPL) have not been investigated before.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
