Platelet distribution width is associated with 1-year all-cause mortality in the elderly population

Abstract

PurposeThe aim of this investigation was to analyze whether the following platelet indices are useful markers for functional dependence and 1-year all-cause hospitalization and mortality in the elderly population: platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and platelet–large cell ratio (P-LCR). MethodsThe 119 participants in this study were 90 women and 29 men between the ages of 68 and 105 years who were selected from the Santa Teresa nursing home (Oviedo, Spain). We studied morbidity, sociodemographic characteristics, and functional status using the Barthel Index (BI) and Katz Index (KI) for activities of daily living. ResultsIn logistic regression models adjusted for age, sex, and anti-inflammatory drug use, low levels of PDW were associated with death at 1 year. When we applied logistic regression models adjusted for morbid conditions as well as age, sex, and anti-inflammatory drug use, the PDW remained statistically significant. No relation between PLT, MPV, or P-LCR and mortality was found. No statistical associations between the platelet indices studied and functional dependence or hospitalization were observed. ConclusionOur data suggest that the PDW could be a predictor of 1-year mortality in the elderly population and may therefore serve as a useful tool for identifying individuals with a high risk of mortality who may benefit from preventative care or early-stage strategies.