Abstract
BackgroundActivated platelets promote tumor cell growth, aberrant angiogenesis, and invasion. However, the value of platelet indices for predicting survival in gastric cancer remains unknown. The goal of this study was to investigate the predictive significance of platelet indices in gastric cancer.ResultReduced platelet distribution width (PDW) was significantly correlated with age, carcinoembryonic antigen, tumor stage, nodule stage, and tumor-nodule-metastases stage. Moreover, decreased PDW correlated with a shorter overall survival in gastric cancer. Multivariate analysis identified PDW as an independent prognostic factor for overall survival (hazard ratio: 0.493, 95% confidence interval: 0.319-0.761, p = 0.001).MethodA total of 294 patients with gastric cancer were retrospectively analyzed between January 2009 and December 2009. The association between platelet indices and overall survival were evaluated. The prognostic analysis was carried out with Cox regression model.ConclusionPDW is easily available with routine blood counts. Our data revealed that reduced PDW is unfavorable prognostic factor in gastric cancer. Further studies are warranted.
Highlights
Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide [1]
platelet distribution width (PDW) is available with routine blood counts
Our data revealed that reduced PDW is unfavorable prognostic factor in gastric cancer
Summary
Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide [1]. Much progress has been made in the diagnosis and treatment of GC in recent years, the rate of diagnosis in early stage is still low and the prognosis of GC remains poor [2, 3]. Recent studies have demonstrated a significant role of platelets during cancer progression and metastases. Elevated platelets are associated with a poor prognosis in various types of cancer, including pancreatic cancer, gastric cancer, colorectal cancer, endometrial cancer, and ovarian cancer [5,6,7,8,9]. The value of platelet indices for predicting survival in gastric cancer remains unknown. The goal of this study was to investigate the predictive significance of platelet indices in gastric cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
