PLATELET DISTRIBUTION WIDTH AS A PROGNOSTIC FACTOR IN THROMBOLYSED ISCHEMIC STROKE

Abstract

Background: Platelet distribution width is one of the routine parameters in platelet indices, and indicates about the volume variability of the platelet size. Platelet distribution width is one of the routine parameters in platelet indices, and indicates about the volume variability of the platelet size. It is measured in percentage. Among the platelet indices, PDW is a better indicator of platelet reactivity than MPV. The clinical examinations and studies have shown that PDW has been a prognostic indicator in thrombolysed ischemic stroke patients. The present study has been aimed to observe PDW as a prognostic indicator in thrombolysed ischemic stroke patients. A Pr Methods: ospective, Single arm observation study was conducted at MGM Institute of Health Sciences, Navi Mumbai where in a total of 60 patients of thrombolysed ischemic stroke satisfying inclusion and exclusion criteria visiting casualty and admitted in medical ICU of MGM Medical College and Hospital, Kamothe, Navi Mumbai were selected for the study. Results: Data analysed showed thrombolysis was done with Alteplase in 49 patients and with Tenecteplase in 11 patients. Hence, data showed that a greater number of patients were thrombolysed with Alteplase. The study showed that 4 died out of 49 thrombolysed with alteplase which equals to 8.16%. 1 died among 11 thrombolysed with tenecteplase which equals to 9.09%. Total 5 died among 60 patients who got thrombolysed which equals to 8.33%. The analysis suggested that 50 out of 60 patients recovered post thrombolysis (83.3%), while 3 out of 60 died (5%). Total 7 patients out of 60 had hemorrhagic transformation post thrombolysis, out of which 5 recovered (8.4%) and remaining 2 out of 7 died (3.3%). The study concluded that s Conclusion: ince, p-value less than that of 0.05 indicates signicant change in PDW when compared between on day of admission to on the day of outcome of all the patients, study concluded that over all there was an increment in PDW. The analysis concluded that majority of the patients had a good outcome post thrombolysis (83.3%).