Abstract
Platelet-derived growth factor-BB (PDGF-BB) improves follicular survival, oocyte and follicular diameters, in a dose-dependent manner, after the in vitro culture of goat preantral follicles enclosed in ovarian tissue fragments
Highlights
Folliculogenesis is defined as the formation of primordial follicles, their recruitment into the growing pool, and their further progression to the preovulatory stage in the ovary (Oktem and Oktay, 2008)
After 1 day of culture, all treatments resulted in lower (P < 0.05) percentages of morphologically normal follicles than the non-cultured control group except when follicles were cultured in the absence of platelet-derived growth factor (PDGF) (0 ng/ml; P > 0.05)
The present study demonstrated for the first time the effects of Platelet-derived growth factor-BB (PDGF-BB) on the in vitro survival, activation, and growth of early caprine preantral follicles enclosed in ovarian tissue
Summary
Folliculogenesis is defined as the formation of primordial follicles, their recruitment into the growing pool, and their further progression to the preovulatory stage in the ovary (Oktem and Oktay, 2008). In this process, proper metabolic bidirectional communication among the oocyte and somatic cells inside the follicle is crucial to control the follicular fate (Van Den Hurk and Zhao, 2005). Understanding the signals responsible for the initiation of folliculogenesis is an important step towards developing a successful in vitro culture system (Chaves et al, 2010) The pattern of gene expression has been analyzed in goats in the transition from secondary to early tertiary follicles, Silva et al PDGF improved the follicular development in vitro
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