Abstract
Aim: To investigate the regenerative effects of a platelet-derived purified exosome product (PEP) on human endometrial cells. Materials & methods: Endometrial adenocarcinoma cells (HEC-1A), endometrial stromal cells (T HESC) and menstrual blood-derived stem cells (MenSC) were assessed for exosome absorption and subsequent changes in cell proliferation and wound healing properties over 48 h. Results: Cell proliferation increased in PEP treated T HESC (p<0.0001) and MenSC (p<0.001) after 6 hand in HEC-1A (p<0.01) after 12 h. PEP improved wound healing after 6 hin HEC-1A (p<0.01) and MenSC (p<0.0001)and in T HESC between 24 and 36 h(p<0.05). Conclusion: PEP was absorbed by three different endometrial cell types. PEP treatment increased cell proliferation and wound healing capacity.
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