Abstract
Platelet count monitoring in burn patients
Highlights
Platelets play an important role in severe hemostasis disorders and immune response impairments in burn patients
The significant between-group differences observed in platelet count on the 4th and 7th day in relation to severity of injury, as well as the significant decrease in platelet count on the 4th day as compared to the 1st day in patients with moderate/severe burns, suggest the need to increase the frequency of platelet count monitoring in this particular period in order to timely identify the decrease in platelet count
Comparing surviving and deceased patients, a significantly lower platelet count was observed in the group of patients with lethal outcome throughout the whole period of observation, with the exception of the 1st day when platelet count was higher in this group
Summary
Platelets play an important role in severe hemostasis disorders and immune response impairments in burn patients. The aim of this study was platelet count monitoring in burn patients in relation to the severity of burn injury (percentage of total body surface area burned - %TBSA) and disease outcome (survival/death). Burned patients are characterized by severe impairment of hemostatic balance and immune response, and platelets play an important role in the modulation of both these responses. The platelet primary function is hemostatic regulation, they act as inflammatory cells They release inflammatory mediators, express proinflammatory surface molecules, interact with leukocytes and endothelial cells, taking part in the induction of acute and chronic immune response (5-7). Cilj ovoga istraživanja bio je praćenje broja trombocita u skupinama bolesnika s različitim postotkom opečene površine tijela (≤ 10% TBSA – skupina A; > 10% TBSA – skupina B), te s obzirom na ishod bolesti (preživljenje/smrt)
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