Abstract
Platelets are an enriched source of growth factors, pro- or anti-inflammatory agents, and pro- or anti-angiogenic mediators which are differentially sorted and readily available to be released from their granular repertoire upon receiving adequate stimulus. Platelet-derived mediators either through an autocrine or paracrine mode of action regulate systemic and vascular inflammation, immune defence, also contribute to regenerative mechanisms. Lately, platelet-associated chemokines have been ascribed rather unconventional roles in thrombo-inflammation, lipid uptake, and antimicrobial defence. This chapter highlights the impact of platelet-associated CXC chemokine ligands and their receptors in modulating haemostasis-thrombosis and platelet life span, and in influencing platelet-induced inflammatory or regenerative processes. We further highlight the contribution of thrombocidins, which are platelet-derived modified chemokines, in executing antimicrobial actions. The recently discovered multifaceted aspects of platelet chemokines as emphasised in this chapter encourages further experimental and clinical investigations in this expansive but still largely uncharted area of research in platelet biology.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
