Abstract
BackgroundThe prognostic significance of the platelet (PLR) and neutrophil (NLR) to lymphocyte ratios for patients with resectable colorectal cancer liver metastases (CLM) was evaluated. MethodsClinicopathologic data from patients who underwent hepatectomy for CLM at two tertiary care hospitals between 1995 and 2017 were collected. Blood counts were evaluated for prognostic significance. Results151 patients met inclusion criteria. The median age was 58 years, 44% were female, and 58% had synchronous metastases. Median number of liver metastases was 2, and 59% of patients underwent lobectomy or extended lobectomy. On multivariable analysis, NLR ≥5 (HR 2.46 [1.08–5.60 CI], p = 0.032), PLR ≥ 220 (HR 2.10 [1.04–4.23 CI], p = 0.037), and greater than 2 liver metastases (HR 2.41 [1.06–5.45 CI], p = 0.035) were associated with reduced overall survival. ConclusionsPLR ≥ 220 and NLR ≥ 5 may have utility as preoperative prognostic markers for overall survival in patients with resectable CLM.
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