Abstract
BackgroundAltered mean platelet volume (MPV) and plasma albumin has been reported in type 2 diabetes (T2D). MPV is suggested to predict cardiovascular risk but there is a lack of evidence for associations between MPV and platelet adhesion. Plasma albumin and magnesium are other factors reported to influence thrombotic risk. The objectives of this study were to assess the association between platelet adhesion and plasma factors with a potential role to affect platelet activation.MethodsBlood was collected from 60 T2D patients and 60 healthy controls. Platelet adhesion to different protein surfaces induced by various soluble activators were measured in microplates. MPV, albumin and magnesium were analysed together with additional routine tests.ResultsDespite normal levels, plasma albumin significantly correlated with adhesion of T2D platelets but not with controls. There was a significant association between MPV and platelet adhesion in both groups, but association was smaller in T2D. Levels of glucose, HbA1c or magnesium did not correlate with platelet adhesion.ConclusionsPlasma albumin was associated with platelet adhesion in T2D suggesting that albumin may be a factor to consider upon cardiovascular risk assessment. MPV was more associated with the level of platelet adhesion in healthy individuals than in well-controlled T2D patients.
Highlights
Platelets play a crucial role in hemostasis with adhesion, aggregation and pro-coagulative function upon tissue damage
Since the impact of Mean platelet volume (MPV), albumin and magnesium on platelet adhesion are not earlier studied in human T2D subjects, the aim of the current study was to investigate how these factors associate with platelet adhesion in type 2 diabetes
Blood was collected in two 7 mL sodium heparin tubes (Becton Dickinson, Oxford, UK) for platelet count, characteristics and adhesion, as well as magnesium and albumin analysis; 3 mL in one EDTA tube for Hemoglobin A1c (HbA1c) and; 4 mL in one sodium fluoride + oxalate tube (Becton Dickinson) for plasma glucose (P-glucose)
Summary
Platelets play a crucial role in hemostasis with adhesion, aggregation and pro-coagulative function upon tissue damage. Patients with Type 2 diabetes (T2D) have increased risk for cardiovascular disease and thrombotic complications compared to controls [2]. Platelets in diabetes have been reported to be characterised by alterations such as increased aggregation or other activation dependent events [1, 3]. Mean platelet volume (MPV) is reported to be significantly increased in subjects with. Altered mean platelet volume (MPV) and plasma albumin has been reported in type 2 diabetes (T2D). MPV is suggested to predict cardiovascular risk but there is a lack of evidence for associations between MPV and platelet adhesion. The objectives of this study were to assess the association between platelet adhesion and plasma factors with a potential role to affect platelet activation
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