Abstract
Many chemicals to which humans are regularly exposed interfere with normal endocrine (hormonal) function, including critical mechanisms underlying brain development. While it is methodologically difficult to directly associate chemical exposures with subsequent manifestations of developmental disabilities, ample evidence exists to justify concern and precautionary action to reduce or eliminate exposures. In this article, we review the literature concerning the endocrine disruptive properties of three commonly encountered classes of substances, plastics, pesticides, and flame retardants (PBDEs), and the mechanisms by which they may be contributing to the apparent increase in prevalence of developmental disabilities. We urge professionals working in disabilities fields to advocate for stronger regulation and public education regarding the toxic properties of such materials.
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