Plasticity after cognitive training reflected in prefrontal local field potentials

Abstract

SummaryLearning to perform a new cognitive task induces plasticity of the prefrontal cortex generally involving activation of more neurons and increases in firing rate; however, its effects on single neurons are diverse and complex. We sought to understand how training affects global measures of neural activity by recording and analyzing local field potentials (LFPs) in monkeys before and after they learned to perform working memory tasks. LFP power after training was characterized by a reduction in power in 20–40 Hz during the stimulus presentations and delay periods of the task. Both evoked power, synchronized to task events, and induced power exhibited this decrease after training. The effect was consistent across tasks requiring memory of spatial location and stimulus shape. Error trials were characterized by a lack of LFP power ramping around the fixation onset. Our results reveal signatures of cortical plasticity in LFPs associated with learning to perform cognitive tasks.