Plastic membrane sensor for the determination of hydroxyzine dihydrochloride in the pharmaceutical formulation

Abstract

The construction and performance characteristics of a plastic membrane potentiometric sensor for the determination of hydroxyzine dihydrochloride were described. The sensor is based on hydroxyzine-tetraphenylborate ion pair as an electroactive species and dibutyl phthalate as a plasticizer. The proposed sensor has a nernstian slope of 58 + 1.23 mV concentration per decade at 25 °C in the concentration range 1.96 × 10−5 – 1 × 10−2 M hydroxyzine dihydrochloride with a detection limit of 6.34 × 10−6 M (2.84 µg/ ml) hydroxyzine dihydrochloride, and the response time was 10 s. The sensor shows good selectivity for the drug over many inorganic cations, sugars, vitamins and, amino acids. The suggested sensor was effectively employed for the determination of the drug in its pharmaceutical formulation Atarax injection and in spiked human urine samples.