Abstract
Plasmonic metasurfaces have been widely used in biosensing to improve the interaction between light and biomolecules through the effects of near-field confinement. When paired with biofunctionalization, plasmonic metasurface sensing is considered as a viable strategy for improving biomarker detection technologies. In this review, we enumerate the fundamental mechanism of plasmonic metasurfaces sensing and present their detection in human tumors and COVID-19. The advantages of rapid sampling, streamlined processes, high sensitivity, and easy accessibility are highlighted compared with traditional detection techniques. This review is looking forward to assisting scientists in advancing research and developing a new generation of multifunctional biosensors.
Highlights
Since wood observed the plasmon phenomenon on the subwavelength metal grating in1902, the development of plasmon has made rapid progress in the last hundred years [1,2,3,4,5,6,7,8,9].Surface plasmon resonance (SPR) is a collective electronic oscillation phenomenon, which could be classified into two main forms, as surface plasmon polarization (SPP) and localized surface plasmon resonance (LSPR), by their different excitation ways [10]
The metasurface-based biosensing we have mentioned above is regarded as an interesting alternative approach, where the feasibility in infectious detection has been widely demonstrated in many studies
We briefly review the applications of plasmonic metasurfaces in biosensing
Summary
Since wood observed the plasmon phenomenon on the subwavelength metal grating in. 1902, the development of plasmon has made rapid progress in the last hundred years [1,2,3,4,5,6,7,8,9]. Compared with the biosensing performance of the important dielectric metasurface counterpart [39,40], plasmonic metasurface has a lower quality (Q) factor of resonance, but their biomolecule sensitivity is usually much higher This is attributed to the greater near-field concentration and confinement, which is typically within the size scope various biomolecules [10]. The metasurface-based biosensing we have mentioned above is regarded as an interesting alternative approach, where the feasibility in infectious detection has been widely demonstrated in many studies Thereby, this technology is a promising technique for the rapid diagnosis of viruses. For either SPR or LSPR, bulk refractive index sensitivity (S), the figure of merit (FOM), and limit of detection (LOD) are very important elements to metasurface-based sensor performance. The LOD is mainly determined by sensitivity and noise level, so it can be improved 5with of 19 low noise detectors and light sources
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