Plasmonic Gold Nanoisland Film for Bacterial Theranostics.

Shih-Hua Tan,Hsuan-Ya Tao,Tsung-Rong Kuo,Che-Chang Chang,Sibidou Yougbaré

doi:10.3390/nano11113139

Shih-Hua Tan, Hsuan-Ya Tao + Show 3 more

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https://doi.org/10.3390/nano11113139

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Abstract

Plasmonic nanomaterials have been intensively explored for applications in biomedical detection and therapy for human sustainability. Herein, plasmonic gold nanoisland (NI) film (AuNIF) was fabricated onto a glass substrate by a facile seed-mediated growth approach. The structure of the tortuous gold NIs of the AuNIF was demonstrated by scanning electron microscopy and energy-dispersive X-ray spectroscopy. Based on the ultraviolet-visible spectrum, the AuNIF revealed plasmonic absorption with maximum intensity at 624 nm. With the change to the surface topography created by the NIs, the capture efficiency of Escherichia coli (E. coli) by the AuNIF was significantly increased compared to that of the glass substrate. The AuNIF was applied as a surface-enhanced Raman scattering (SERS) substrate to enhance the Raman signal of E. coli. Moreover, the plasmonic AuNIF exhibited a superior photothermal effect under irradiation with simulated AM1.5 sunlight. For photothermal therapy, the AuNIF also displayed outstanding efficiency in the photothermal killing of E. coli. Using a combination of SERS detection and photothermal therapy, the AuNIF could be a promising platform for bacterial theranostics.

Highlights

IntroductionPlasmonic nanomaterials have been extensively utilized for diagnostic applications because of their unique properties, such as a large surface area, easy surface modification, and distinct surface plasmon resonance [1,2,3,4,5,6,7,8,9,10]
Plasmonic gold nanoparticle (NP; AuNP) multilayers with a superior photothermal effect were fabricated as a sample substrate to assist the desorption and ionization of a bone biomarker, hydroxyproline, for its detection by mass spectrometry [18]
A facile seed-mediated growth approach was applied to deposit an AuNIF onto a glass substrate

Summary

Introduction

Plasmonic nanomaterials have been extensively utilized for diagnostic applications because of their unique properties, such as a large surface area, easy surface modification, and distinct surface plasmon resonance [1,2,3,4,5,6,7,8,9,10]. Gold-based nanomaterials with tunable size and shape have been extensively applied for biomedical detection based on their optical and structural characteristics [11,12,13,14,15,16,17]. Peptidenucleic-acid-conjugated gold nanorods were designed for the sequence-specific detection of circulating tumor DNA point mutations according to changes in their surface plasmon resonance absorbances [19].

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