Abstract
We retrospectively analyzed epidemiologic, clinical, and biologic characteristics of 368 Plasmodium ovale wallikeri and 309 P. ovale curtisi infections treated in France during January 2013–December 2018. P. ovale wallikeri infections displayed deeper thrombocytopenia and shorter latency periods. Despite similar clinical manifestations, P. ovale wallikeri–infected patients were more frequently treated with artemisinin-based combination therapy. Although the difference was not statistically significant, P. ovale wallikeri–infected patients were 5 times more frequently hospitalized in intensive care or intermediate care and had a higher proportion of severe thrombocytopenia than P. ovale curtisi–infected patients. Rapid diagnostic tests that detect aldolase were more efficient than those detecting Plasmodium lactate dehydrogenase. Sequence analysis of the potra gene from 90 P. ovale isolates reveals an insufficient polymorphism for relapse typing.
Highlights
By using quantitative PCR (qPCR)-HRM for species differentiation, we identified 368 P. ovale wallikeri and 309 P. ovale curtisi infections
Patients’ Demographic and Epidemiologic Characteristics P. ovale wallikeri and P. ovale curtisi showed similar repartition by month, except for October, which showed an increase in P. ovale wallikeri infections and a decrease in P. ovale curtisi cases (Figure 2, panel A)
Our findings show that patients infected with P. ovale wallikeri displayed deeper thrombocytopenia than those infected with P. ovale curtisi (p
Summary
Physicians should claim only the credit commensurate with the extent of their participation in the activity. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
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