Abstract
Two cases of Plasmodium knowlesi infection in humans were identified in Cambodia by 3 molecular detection assays and sequencing. This finding confirms the widespread distribution of P. knowlesi malaria in humans in Southeast Asia. Further wide-scale studies are required to assess the public health relevance of this zoonotic malaria parasite.
Highlights
Two cases of Plasmodium knowlesi infection were identified in humans in Cambodia by 3 molecular detection assays and sequencing
The main objective of this study was to develop evidence to guide the management of malaria parasite–negative persons with acute febrile illness and to determine whether such persons were infected with P. knowlesi
Our findings confirm that P. knowlesi infections occur in humans in Cambodia, thereby increasing the number of countries in Southeast Asia with cases in humans [10]
Summary
Two cases of Plasmodium knowlesi infection were identified in humans in Cambodia by 3 molecular detection assays and sequencing. This finding confirms the widespread distribution of P. knowlesi malaria in humans in Southeast Asia. No studies in humans [3] and monkeys in Cambodia have identified the simian malaria parasite, P. knowlesi, which is causing human disease in some other countries in Southeast Asia [4]. The main objective of this study was to develop evidence to guide the management of malaria parasite–negative persons with acute febrile illness and to determine whether such persons were infected with P. knowlesi. For the past decade, the number of reported malaria cases has generally decreased but in a sawtooth pattern of periodic increases [1]
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