Abstract
Plasmodium knowlesi was known as a plasmodium of macaques until P. knowlesi transmission to humans was recognised in Borneo and later throughout South-East Asia. We describe here a case of a P. knowlesi infection imported to Germany from Thailand. The patient had not taken antimalarial chemoprophylaxis and suffered from daily fever attacks. Microscopy revealed trophozoites and gametocytes resembling P. malariae. P. knowlesi malaria was confirmed by PCR.
Highlights
With a diagnosis of malaria and acute renal failure, the patient was referred to our Tropical and Infectious Diseases service
A naturally acquired human infection was reported 1965 in a citizen of the United States returning from Malaysia [6]
Thereafter, human P. knowlesi infections were reported only occasionally until 2004, when a study by Singh et al revealed that P. knowlesi accounted for more than 50% of endemic human
Summary
Citation style for this article: Orth H, Jensen BO, Holtfreter MC, Kocheril SJ, Mallach S, MacKenzie C, Müller-Stöver I, Henrich B, Imwong M, White NJ, Häussinger D, Richter J. In January 2013, a 55 year-old German woman presented to her practitioner because of fever, nausea and vomiting ten days after a holiday in Thailand. The procalcitonine level rose to 3.71 ng/mL, interleukin-6 to 66.8 pg/mL, haematocrit fell to 29.7%, and microscopy of stained blood films revealed malaria parasites, but the hospital’s microbiologist reported that he felt unable to identify a specific Plasmodium species. The sequence of the amplified genus-specific DNA was homologous with the species P. knowlesi Infection by this parasite was confirmed by a specific PCR in the Faculty of Tropical Medicine, Mahidol University Bangkok, Thailand. With intravenous isotonic saline administration, urine output was restored and serum creatinine fell to 1.3 mg/dL on Day 4
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