Abstract
Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples. Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy.
Highlights
Mutations in the propeller domain of the Plasmodium falciparum kelch[13] (k13) gene are associated with artemisinin resistance
We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples
Conclusions: the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy
Summary
Mutations in the propeller domain of the Plasmodium falciparum kelch[13] (k13) gene are associated with artemisinin resistance. Abstract Introduction: Mutations in the propeller domain of the Plasmodium falciparum kelch[13] (k13) gene are associated with artemisinin resistance.
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