Abstract
Background Histidine rich protein 2 (HRP2) produced by Plasmodium falciparum is the target of most P. falciparumdetecting Rapid Diagnostic Tests (RDTs) as well as of P. falciparum in vitro drug susceptibility assays. Likewise histidine rich protein 3 (HRP3) is recognized to a minor proportion. Deletion of either pfhrp2 or pfhrp3 or both genes have been reported in P. falciparum parasites and can affect the RDT’s expected performance [1,2].
Highlights
Histidine rich protein 2 (HRP2) produced by Plasmodium falciparum is the target of most P. falciparumdetecting Rapid Diagnostic Tests (RDTs) as well as of P. falciparum in vitro drug susceptibility assays
Materials and methods 275 blood samples of P. falciparum collected on filter paper from 2003 to 2012 from seven malaria endemic localities in Colombia were evaluated
The presence of the pfhrp2 and pfhrp3 genes was tested by nested PCR amplification of two fragments of both genes
Summary
Histidine rich protein 2 (HRP2) produced by Plasmodium falciparum is the target of most P. falciparumdetecting Rapid Diagnostic Tests (RDTs) as well as of P. falciparum in vitro drug susceptibility assays. Deletion of either pfhrp or pfhrp or both genes have been reported in P. falciparum parasites and can affect the RDT’s expected performance [1,2]
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