Plasmodium berghei infection in mice: effect of low-level ozone exposure.

Abstract

Animal and human studies have accumulated that report extrapulmonary effects from inhaled ozone (OR). Buckley et al. (1975) exposed human volunteers to 0.5 p~m O R for 2.75 h and demonstrated increases in red cell f ragi l i ty~ serum vitamin E levels, and red cell glucose-6-phosphate dehydrogenase (G-6-PD) act ivi ty. Decreases in red cell acetylcholinesterase (ACHase) act ivi ty and reduced glutathione (GSH) were also evident. Similar results were obtained by Hackney et al. (1977) who exposed human male volunteers to 0.37 ppm 0 R for 2.0 hours. Moore et al. (1981) exposed sheep to 0.25, 0.50, or 0.70 ppm of O R for 2.75 h and observed a decreased erythrocyte survival tTme as determined by CR-51 studies. Exposure of male Sprague-Dawley rats to 0.3 ppm O R for 3 h resulted in a time-delayed increase in serum and hepatic reduced ascorbic acid levels as compared to controls (Calabrese et al. 1983).