Abstract
Severe malaria is a complex multisystem disorder includ-ing complications such as cerebral malaria, anemia, aci-dosis, jaundice, respiratory distress, renal insufficiency,coagulation anomalies and hyperparasitemia. We previ-ously characterized the experimental cerebral syndromeusing in vivo MRI and MRS techniques and proved thepreponderant role of edema in the fatal outcome of exper-imental cerebral malaria (CM) [1]. The purpose of the cur-rent study was to examine the cerebral effects ofPlasmodium berghei ANKA (PbA) infection in a mousestrain resistant to CM. We tested the hypothesis that PbAinfection could elicit brain injury, despite the absence ofexperimental CM, and by mechanisms different fromthose involved in CM.
Highlights
Severe malaria is a complex multisystem disorder including complications such as cerebral malaria, anemia, acidosis, jaundice, respiratory distress, renal insufficiency, coagulation anomalies and hyperparasitemia
We previously characterized the experimental cerebral syndrome using in vivo MRI and MRS techniques and proved the preponderant role of edema in the fatal outcome of experimental cerebral malaria (CM) [1]
The purpose of the current study was to examine the cerebral effects of Plasmodium berghei ANKA (PbA) infection in a mouse strain resistant to CM
Summary
Severe malaria is a complex multisystem disorder including complications such as cerebral malaria, anemia, acidosis, jaundice, respiratory distress, renal insufficiency, coagulation anomalies and hyperparasitemia. We previously characterized the experimental cerebral syndrome using in vivo MRI and MRS techniques and proved the preponderant role of edema in the fatal outcome of experimental cerebral malaria (CM) [1]. The purpose of the current study was to examine the cerebral effects of Plasmodium berghei ANKA (PbA) infection in a mouse strain resistant to CM. We tested the hypothesis that PbA infection could elicit brain injury, despite the absence of experimental CM, and by mechanisms different from those involved in CM
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