Abstract
We measured plasminogen activator inhibitor-1 levels in the cerebrospinal fluid and plasma of newborns with and without posthemorrhagic hydrocephalus. We found that plasminogen activator inhibitor-1 levels in the cerebrospinal fluid of healthy newborns are <10 mg/mL but are greatly elevated in patients who have posthemorrhagic hydrocephalus and correlate directly with cerebrospinal fluid D-dimer and protein levels. (J Pediatr 2000;137:132-4.)
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