Abstract
BackgroundThe onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA.MethodsEligible patients with hip joint diseases who were scheduled for unilateral primary THA at our hospital were prospectively included into this study. The demographic and clinical features, preoperative plasma biomarkers were detailed, recorded, and compared. The multiple logistic regression analysis was used to evaluate potential risk factors for DVT.ResultsA total of 214 subjects were enrolled into our study cohort for the final analysis, and 23 of them have suffered DVT with an incidence of 9.5%. The performance of logistic regression analysis showed that preoperative expression of plasminogen activator inhibitor-1 (PAI-1) was an independent risk factor for the onset of DVT in patients after THA (OR 1.18, 95% CI 1.04–1.29; p = 0.011).ConclusionsOur study indicated preoperative plasma PAI-1 expression as an independent risk factor for DVT in patients who underwent THA.
Highlights
The onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality
Previous studies in western populations have reported the incidence of deep vein thrombosis (DVT) in THA patients can be as high as 40–60% with no appropriate chemoprophylaxis [2]
The remaining 214 subjects were enrolled into our study cohort for the final analysis, and 23 of them have suffered DVT with an incidence of 9.5% (5 patients were symptomatic)
Summary
The onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA. Venous thromboembolism (VTE) is recognized as one of most common complications during patients undergoing total hip arthroplasty (THA) and can be closely related to postoperative mortality with uncertain prophylaxis [1]. Previous studies in western populations have reported the incidence of deep vein thrombosis (DVT) in THA patients can be as high as 40–60% with no appropriate chemoprophylaxis [2]. Whether PAI-1 can serve as a risk factor for DVT in patients undergoing THA still remains unknown. The purpose of our present study was to investigate potential risk factors for DVT after THA
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