Abstract
Plasmepsin V, a Secret Weapon Against Malaria
Highlights
Plasmodium falciparum and Plasmodium vivax are single-celled parasites that, between them, are responsible for the vast majority of malaria cases in humans
The parasites express and secrete more than 450 proteins. Each of these proteins has a different function for the parasite, but many of them share a distinctive feature: an aminoterminal motif called the Plasmodium EXport ELement (PEXEL)
Following exposure to the drug, only cells that have integrated the construct will survive. When this approach was attempted with Plasmepsin V (PMV) in the malaria parasites P. falciparum and P. berghei, no drug-resistant parasites were recovered
Summary
Plasmodium falciparum and Plasmodium vivax are single-celled parasites that, between them, are responsible for the vast majority of malaria cases in humans. The parasites express and secrete more than 450 proteins. Each of these proteins has a different function for the parasite, but many of them share a distinctive feature: an aminoterminal motif called the Plasmodium EXport ELement (PEXEL).
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