Plasmatic Markers Of Coagulation And Fibrinolysis In Patients With C1 Inhibitor Deficiency During Acute Attacks Of Angioedema

Abstract

RATIONALE: C1-INH controls protease activity in complement, contact, coagulation and fibrinolytic systems. Its deficiency causes recurrent angioedema of the skin, bowel mucosa and upper airway. Aim of this study was the identification of plasmatic markers to distinguish angioedema due to C1-INH deficiency. Since activation of fibrinolytic system and generation of thrombin occur during angioedema in C1-INH deficiency, we used commonly available methods to measure prothrombin fragment F1+2 and fibrin fragment D-Dimer as markers of thrombin generation and fibrinolysis.