Abstract
A row of analytical methods for determining neuroleptics in blood has been developed with the aim of improving antipsychotic treatment by plasma concentration monitoring. Perphenazine in an optimal therapeutic plasma concentration range between 2 and 3 nmol/1 (measured as minimum concentrations) has been found in orally treated patients. This range corresponds to the range 2-6 nmol/l during the entire dose interval. Consequently, the range 2-6 nmol/l is referred to during parenteral depot administration.Depot treatment with perphenazine enanthate is often problematic, especially within the first few days of the injection. This can be explained by significant fluctuations of the plasma concentration within a depot interval. Therefore, lower doses with shorter intervals are to be recommended. Lately, a new depot preparation - perphenazine decanoate - has been introduced disclosing much smaller fluctuations of the plasma level and therefore fewer side effects.It has been shown that both disulfiram and diazep...
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