Plasmacytoma-Associated Neuronal Glycoprotein,Pang,Maps to Mouse Chromosome 6 and Human Chromosome 3

Abstract

A new member of the immunoglobulin/fibronectin superfamily of adhesion molecules,Pang(plasmacytoma-associated neuronal glycoprotein), was recently isolated from a plasmacytoma. In previous studies,Pangwas found to be normally expressed in the brain and ectopically activated by intracisternal A-type particle long terminal repeats in plasmacytomas. In this study,Pangwas initially mapped to mouse Chr 6 by somatic cell hybrid analysis and further positioned on the chromosome betweenWnt7aandPcp1.Southern blot analysis of human–rodent somatic cell hybrids together with predictions from the mouse map location indicate that human PANG is located at 3p26.