PLASMACYTOMA AND PLASMA CELL MYELOMA AFFECTING THE JAWS: A MULTI-INSTITUTIONAL COLLABORATIVE STUDY.

Abstract

Plasma cell neoplasms represent the proliferation of single clones of plasma cells with monoclonal immunoglobulin production. This study aimed to report a case series of plasmacytoma (PMC) and multiple myeloma (MM) of the oral cavity. Data were retrospectively retrieved and clinical, radiographic, microscopic, immunohistochemistry, and follow-up status were collected. Fifty-two cases were included (28 PMC and 24 MM), with a mean age of 59.4 years (range 27-88) and no sex predilection. Lesions were mostly presented as painful swellings in the mandible. Radiographic aspects showed poorly defined multilocular lesions, while microscopic examinations showed a proliferation of plasma cells with abundant eosinophilic cytoplasm. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, with a predominance of kappa light chain monoclonality. Overall survival was poor, and after 5 years, 26.6% of the patients were still alive. PMC and MM are aggressive neoplasms with a poor prognosis for affected patients. Plasma cell neoplasms represent the proliferation of single clones of plasma cells with monoclonal immunoglobulin production. This study aimed to report a case series of plasmacytoma (PMC) and multiple myeloma (MM) of the oral cavity. Data were retrospectively retrieved and clinical, radiographic, microscopic, immunohistochemistry, and follow-up status were collected. Fifty-two cases were included (28 PMC and 24 MM), with a mean age of 59.4 years (range 27-88) and no sex predilection. Lesions were mostly presented as painful swellings in the mandible. Radiographic aspects showed poorly defined multilocular lesions, while microscopic examinations showed a proliferation of plasma cells with abundant eosinophilic cytoplasm. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, with a predominance of kappa light chain monoclonality. Overall survival was poor, and after 5 years, 26.6% of the patients were still alive. PMC and MM are aggressive neoplasms with a poor prognosis for affected patients.