Abstract
To evaluate the release and possible role of N-terminal end of atrial natriuretic factor (ANF) prohormone (proANF-1–30) and C-terminal end of ANF prohormone ( aANP-1–28) in patients with soft tissue and bone injuries, 20 patients with soft tissue injuries, 18 bone-fractured patients, and 21 healthy controls were examined. Samples were collected from patients within 24 h after injury. Plasma level of proANF-1–30 and aANP-1–28 were higher in orthopedic patients than the soft tissue injury patients compared to controls ( P < 0.005, P < 0.05, respectively). proANF-1–30 was over 15-fold greater than aANP-1–28 in the healthy control samples. These data hypothesized that the concentration of proANF-1–30 may be related to tissue damages in man.
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