Abstract
This study described the clinical and histopathologic data of 6 cases diagnosed as oral plasmablastic lymphoma (PBL) retrieved from the files of 2 Brazilian oral pathology services from 2000 to 2018. The mean age at presentation was 41.5 years, with a male predominance of 2:1. Involved sites were the palate, maxillary mucosa, and mandibular mucosa. All cases presented as a combination of ill-defined swellings and ulcers, with pain or bleeding. Histopathologic features revealed the proliferation of large cells, with round to ovoid eccentric nuclei, and peripheral nucleoli, as well as plasmablastic cells with prominent nucleoli. The cases were positive for CD138 and plasma cell, negative for CD20, and presented with a high proliferative index (>90%). All cases were positive for Epstein-Barr virus-encoded small ribonucleic acids (EBER). Treatment included chemotherapy associated with highly active antiretroviral therapy (HAART). Radiotherapy was performed in 1 case and HAART only was applied in 1 case. Currently, 4 patients remain alive.
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