Abstract
Plasmablastic lymphoma is non-Hodgkin's lymphoma usually found in the head and neck region. It is a rare and aggressive subtype of B-cell lymphoma that affects, in most cases, HIV-positive individuals; it has a propensity for the oral cavity, presenting primary oral lesion with superficial ulceration and mass of rapid evolution as the only clinical finding. A 24-year-old seropositive man was referred to an oral pathology center presenting with a 2-month history of lesion in the left posterior mandible. Clinically, there was a lesion with no defined limits, involving teeth with a high degree of mobility. An incisional biopsy was performed. The anatomopathologic examination revealed a proliferation of diffuse neoplastic cells, and immunohistochemical reactions were positive for leukocyte common antigen and CD-138, showed high Ki-67, and were negative for CD-20 and CD-3, concluding the diagnosis of plasmablastic lymphoma. The patient was referred to a hematology center to start treatment.
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