Abstract
We thank Dr Saito for the interest in our paper "Effects of different mean arterial pressure targets on plasma volume, ANP and glycocalyx-A randomized trial" where cardiac surgery patients were randomised to a mean arterial pressure (MAP) of 60 or 90 mm Hg using norepinephrine (NE) infusion.1,2 The plasma volume (PV) and the Mid Regional-pro Atrial Natriuretic Peptide (MR-proANP) increased in the group randomised to lower MAP. All patients had a normal left ventricular ejection fraction of 45% or more.
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