Abstract
Purpose of Investigation: The objectives of this study were to evaluate urotensin 2 (UT-2) serum levels, a potent vasoconstrictor, in women with irregular menstrual irregularities and to determine its course in irregular menstrual cycles for the first time in the literature. It aims to determine the possible physiological roles of UT-2 by comparing the hormonal changes occurring in women with menstrual irregularities and their UT-2 levels. Materials and Methods: In this study, 120 patients with irregular menstruation was collected on day 3 of the menstrual cycle. Patients were divided into four groups: oligomenorrhea, hypomenorrhea, polymenorrhea, and menorrhagia/ menometrorrhagia. Follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), prolactin (PRL), and UT-2 levels were measured in serum. Results: Serum FSH, LH, and TSH levels were not significantly different between the groups. In this study a correlation test between UT-2 and PRL levels was carried out. This resulted in a statistically inverse correlation between increased UT-2 and decreased PRL levels among the groups being shown. Conclusion: It is interesting to note that the levels of urotensin in this study were higher in women with menstrual irregularities than in healthy individuals and that serum PRL levels in women with menstrual irregularities were lower than those in the control group, while still remaining within normal range.
Highlights
Irregular menstruation, an important public health problem, leads to serious problems both in a social sense and in terms of the state budget
Patients whose menstrual irregularities were determined after the evaluation of the patients by a specialist physician were divided into four groups, and evaluated
Women with menstrual irregularities were first initially assessed for transition to menopause and to pathophysiology of irregularity
Summary
An important public health problem, leads to serious problems both in a social sense and in terms of the state budget. Increased or more frequent menstrual bleeding is defined as abnormal uterine bleeding. Endocrinological causes: irregular bleeding is most often due to anovulation [3, 4]. In the absence of postovulatory progesterone, ovarian estradiol production stimulates endometrial proliferation until bleeding occurs. Such bleeding where there is no other organic pathology other than anovulation is termed “dysfunctional uterine bleeding” (DUB) [5, 6]. While the most common cause of DUB is anovulation, it can be seen in ovulatory patients. Hormonal causes in anovulatory patients with abnormal bleeding should be investigated [7]. As in adenomas with increased prolactin (PRL) or growth hormone secretion, primary pituitary diseases can lead to anovulation. Increased PRL secretion is frequently seen in patients with secondary amenorrhea in particular [10]. In the case of hyperprolactinemia, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) suppression is seen [11]
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